Beta-lactamases in P. aeruginosa: A threat to clinical therapeutics
نویسنده
چکیده
Acquired resistance is through the production of AmpC Beta Lactamases (AmpC), Extended Spectrum Beta Lactamases (ESBL) and Metallo Beta-Lactamases Enzymes (MBL). Resistance to β-lactam antibiotics is associated with production of ESBL which can hydrolyze oxyimino β-lactams such as cefotaxime, ceftriaxone, ceftazidime and monobactams, however, without any effect on cephamycins, carbapenems and related compounds [4,5]. AmpC β-lactamases preferentially hydrolyze cephalosporins and cephamycins and resist inhibition by clavulanate, sulbactam and tazobactam. MBLs hydrolyze carbapenems and other beta-lactams. Resistance to carbapenems is of great concern as these are considered to be antibiotics of last resort to combat infections by multidrug-resistant bacteria [6].
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